Charles Darwin had a non-conformist background, but attended a Church of England school. He studied Anglican theology with the aim of becoming a clergyman, before joining the Voyage of the Beagle. On return, he developed his theory of natural selection in full awareness that it conflicted with the teleological argument. Darwin deliberated about the Christian meaning of mortality and came to think that the religious instinct had evolved with society. With the death of his daughter Annie, Darwin lost all faith in a beneficent God and saw Christianity as futile. He continued to give support to the local church and help with parish work, but on Sundays would go for a walk while his family attended church. However, at the time of writing On the Origin of Species he remained a theist, convinced of the existence of God as a First Cause.

In his later life, Darwin was frequently asked about his religious views. He went as far as saying that "Science has nothing to do with Christ, except insofar as the habit of scientific research makes a man cautious in admitting evidence. For myself, I do not believe that there ever has been any revelation. As for a future life, every man must judge for himself between conflicting vague probabilities." However, he was always insistent that he was agnostic and had "never been an atheist".